S-Adenosyl-L-methionine

S-Adenosyl-L-methionine (SAMe, ademetionine) is a sulfonium compound formed in living cells from the amino acid L-methionine and adenosine triphosphate (ATP), supplied by Nustras as a powder for nutritional use. It is the principal methyl-group donor in biochemical methylation reactions. The commercial stabilised salt form offered is stated on the specification sheet.

It is formulated into dietary supplements, enteric-coated and film-coated tablets, capsules and blister-packed finished products where an S-adenosylmethionine source is specified; because of its sensitivity it is normally processed under low humidity.

The material is a powder; CAS 29908-03-0, molecular formula C15H22N6O5S (free base), molecular weight 398.4. Assay, (S,S)-isomer content, water content and related substances are standardised to specification; identity and assay are confirmed by HPLC, and heavy-metal and microbial limits are supplied to specification and confirmed on each lot's certificate of analysis. The compound is hygroscopic and sensitive to heat and moisture, and is stored sealed under refrigeration.

Nustras supplies S-adenosyl-L-methionine in bulk commercial quantities, in sealed moisture-barrier packaging and fibre drums, to manufacturers and formulators internationally, with a certificate of analysis, specification sheet and country-of-origin documentation on every lot. SAMe is sold as a supplement ingredient in some markets and regulated as a medicinal substance in others; buyers confirm its status and the permitted level for their application. Contact us for grade, pricing per kilogram and lead time.